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Navigate to the Grade Book in your course.
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On any page within the Grade Book, find and click on the Settings button towards the top right. 
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Select the "Calculation Options" tab.
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Fill in the bubble next to the Grading System that you wish to use, such as the Weighted Grading System in the screenshot below. Most instructors will utilize either Weighted or Points Grading Systems, but there is an option for creating a custom Formula as well. Please note that the SUNY Online Help Desk cannot assist with the creation of, or any edits to, a custom Formula.

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Click Save to save your changes, and Yes when asked to confirm your changes. Clicking Close will then exit the Settings area and return you to the Manage Grades page of the grade book.